November 2, 2010
GWAS
Any gene (allele) that caused disease by itself would be strongly selected against. A more realistic scenario is an allele that causes a disease when paired with some independent alleles and prevents disease when paired with other independent alleles. This would not be discovered with current study designs. An allele that caused disease only when paired with some other alleles (never prevented disease) wouldn't even be found. The fact that this is not mentioned in this story and not mentioned in much of the gene/disease association study literature makes me angry. I feel like everyone is stupid or hiding the truth on purpose.
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